New York City, December 13, 2005 -- Manhattan Scientifics Inc. (OTC BB: MHTX) announced today that it has sold its equity interest in a Singapore-based licensee for nearly $900,000. The company intends to use the sale proceeds to retire a significant portion of its debt.

Jack Harrod, COO of Manhattan Scientifics Inc., said, “In 2004, we signed a non-exclusive worldwide license agreement with a Singapore company with operations in Shanghai to manufacture and sell our mid-range fuel cell technology. The license included an upfront license fee, royalty on products sold, gross revenue sharing on non-fuel cell products and an equity interest in that company. We have now sold back our equity interest and our interest in the company’s non-fuel cell products.”

Manhattan Scientifics continues to be a licensor of its patented fuel cell engine technology to the Singapore company and anticipates potential future royalty revenue as a result of that license.

CEO Marvin Maslow said, “Our focus now is to identify a strong Asian manufacturing partner to co-manufacture the NovArs hydrogen fuel cell engine with us. This small, lightweight engine will drive electric scooters and bicycles and is designed to be capable of moving people long distances inexpensively by converting hydrogen into electricity to power the vehicles. An infrastructure of inexpensive hydrogen gas fuel is anticipated to become available as the market for hydrogen-based fuel cells develops in China and elsewhere in Asia. Manhattan Scientifics’ goal is to be a leader in this industry.”

About Manhattan Scientifics
Manhattan Scientifics, Inc., http://www.mhtx.com, is a technology development company working in the fields of alternative energy, fuel cell technologies and computer haptics technology. The company’s facilities are in Los Alamos, Albuquerque and New York City. Copies of Manhattan Scientifics’ press releases, current quotes, stock charts and other investor information may be found at http://www.hawkassociates.com and http://www.americanmicrocaps.com.

An investment profile about Manhattan Scientifics may be found at http://www.hawkassociates.com/mhtx/profile.htm.

About Manhattan Scientifics

Manhattan Scientifics, Inc., http://www.mhtx.com , is a technology development company involved in alternative energy systems with facilities in Los Alamos, Albuquerque and New York City.

The foregoing press release contains forward-looking statements (including expectation of future events), which are subject to risks and uncertainties that may be beyond the company's control. Actual results could differ materially for many reasons including, but not limited to, completion of R&D and successful commercialization of products/services, patent completion and prosecution and defense against well-capitalized competitors. These are serious risks and there is no assurance that our forward-looking statements will occur or prove to be accurate.

Executive Contacts:

Marvin Maslow, CEO, Manhattan Scientifics (917) 923-3300.
Email:maslow@ix.netcom.com

Jack Harrod
Chief Operating Officer
Manhattan Scientifics, Inc.
214.675.8033
Email:harrod@airmail.net

Investor Relations Contact:
Frank Hawkins, (Hawk Associates) (305) 852-2383
Email: Info@hawkassociates.com