MANHATTAN SCIENTIFICS AND LOS ALAMOS NATIONAL LABORATORY SIGN LICENSING PARTNERSHIP AGREEMENT

January 20, 2009

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Manhattan Scientifics (Pink Sheets:MHTX) today announced that it successfully completed and entered into an exclusive license agreement with the Los Alamos National Laboratory. This new agreement pertains to the improved manufacturing techniques and medical use applications for Los Alamos National Laboratory’s nano-structured metals and alloys technology.

Manhattan Scientifics recently announced FDA approval of its nano-titanium dental implants. Manhattan Scientifics’ Metallicum division is planning to manufacture these nano-titanium implants at Danlin Products, Manhattan Scientific’s affiliated manufacturing partner in Albuquerque, NM.

MHTX's nano-structured metals also have wide implications for use in the medical device and prosthetics industries including cardiovascular stents, dental implants, and replacements for hips, shoulders and knees. Clinical studies have shown that bone integrates with these new metals up to 20 times faster than with conventional metals. This means faster healing after surgery and ultimately longer life for nano-structured metal implants.

Manhattan Scientifics' acquisition of Metallicum Inc. was an important step towards formulating its new business model, positioning itself as a "green" technology development company.

About Manhattan Scientifics

Manhattan Scientifics, Inc., http://www.mhtx.com/, is located in New Mexico, New York, and Montreal. It is developing and plans to acquire technologies in a variety of
environmentally friendly energy and other people-friendly industries. Copies of Manhattan Scientifics' press releases and related investor information may also be
found at http://www.hawkassociates.com/.

This press release contains forward-looking statements. Such forward-looking statements are subject to a number of risks, assumptions and uncertainties that could cause
the Company's actual results to differ materially from those projected in such forward-looking statements. Forward-looking statements speak only as of the date made and
are not guarantees of future performance. We undertake no obligation to publicly update or revise any forward-looking statements.

Executive Contacts:

Manny Tsoupanarias
Email: mtsoupanarias@manhattan-scientifics.com
Phone: 918-919-0370

Metallicum, Inc. - Dr. Terry Lowe
Email: tlowe@metallicum.com
Phone: 505-670-8755

For Investor Relations contact MHTX Chairman Emeritus Marvin Maslow
Email: marvin@marvinmaslow.com
Phone: 917-923-3300

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